Predicted to enable serine-type peptidase activity. Involved in cognition. Predicted to be located in extracellular region and membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMPRSS11E. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMPRSS11E upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMPRSS11E, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:68,281,444–68,282,662 | 165.4 kb | Distal (>10kb) Multiome | 168 | |
| chr4:68,349,345–68,350,702 | 97.4 kb | Distal (>10kb) Multiome | 948 | |
| chr4:68,367,612–68,368,369 | 79.5 kb | Distal (>10kb) Multiome | 161 | |
| chr4:68,373,452–68,373,931 | 73.7 kb | Distal (>10kb) Multiome | 134 | |
| chr4:68,375,788–68,376,579 | 71.2 kb | Distal (>10kb) Multiome | 197 | |
| chr4:68,403,598–68,408,126 | 40.0 kb | Distal (>10kb) Multiome | 393 | |
| chr4:68,447,299–68,447,521 | at TSS | At TSS | 50 | |
| chr4:68,451,354–68,451,493 | 3.9 kb | Proximal (<10kb) | 14 | |
| chr4:68,451,808–68,452,227 | 4.3 kb | Proximal (<10kb) | 179 | |
| chr4:68,452,501–68,452,649 | 5.0 kb | Proximal (<10kb) | 15 | |
| chr4:68,452,985–68,453,408 | 5.5 kb | Proximal (<10kb) | 28 | |
| chr4:68,693,329–68,694,483 | 246.4 kb | Distal (>10kb) Multiome | 205 |
Genomic view of the TMPRSS11E locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.