Enables nuclear androgen receptor binding activity and transcription coactivator activity. Involved in androgen receptor signaling pathway and positive regulation of transcription by RNA polymerase II. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:68,931,297–68,933,078 | 119.7 kb | Distal (>10kb) Multiome | 419 | |
| chr3:69,012,112–69,014,102 | 38.7 kb | Distal (>10kb) Multiome | 935 | |
| chr3:69,079,501–69,080,755 | 28.0 kb | Distal (>10kb) Multiome | 569 | |
| chr3:69,084,409–69,085,904 | 32.6 kb | Distal (>10kb) Multiome | 707 | |
| chr3:69,288,126–69,288,883 | 236.2 kb | Distal (>10kb) Multiome | 254 | |
| chr3:69,290,108–69,290,999 | 238.3 kb | Distal (>10kb) Multiome | 171 |
Genomic view of the TMF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.