Involved in intracellular pH reduction; positive regulation of canonical Wnt signaling pathway; and proton-transporting V-type ATPase complex assembly. Located in bounding membrane of organelle; intercellular bridge; and mitotic spindle. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:200,890,766–200,892,246 | 263.1 kb | Distal (>10kb) Multiome | 761 | |
| chr1:200,915,808–200,916,700 | 238.2 kb | Distal (>10kb) Multiome | 219 | |
| chr1:201,014,162–201,014,786 | 140.0 kb | Distal (>10kb) Multiome | 160 | |
| chr1:201,020,041–201,020,958 | 134.1 kb | Distal (>10kb) Multiome | 289 | |
| chr1:201,021,071–201,021,621 | 133.2 kb | Distal (>10kb) Multiome | 164 | |
| chr1:201,022,936–201,024,467 | 130.8 kb | Distal (>10kb) Multiome | 436 | |
| chr1:201,113,946–201,115,250 | 40.1 kb | Distal (>10kb) Multiome | 594 | |
| chr1:201,153,600–201,155,169 | 10 bp | At TSS Multiome | 713 | |
| chr1:201,170,516–201,172,002 | 16.5 kb | Distal (>10kb) Multiome | 988 | |
| chr1:201,222,630–201,223,188 | 68.5 kb | Distal (>10kb) Multiome | 296 | |
| chr1:201,259,443–201,260,371 | 105.4 kb | Distal (>10kb) Multiome | 253 | |
| chr1:201,283,211–201,283,740 | 129.0 kb | Distal (>10kb) Multiome | 190 | |
| chr1:201,309,328–201,309,792 | 155.2 kb | Distal (>10kb) Multiome | 527 | |
| chr1:201,347,882–201,348,374 | 193.7 kb | Distal (>10kb) Multiome | 172 | |
| chr1:201,374,380–201,374,853 | 220.1 kb | Distal (>10kb) Multiome | 43 | |
| chr1:201,376,377–201,377,141 | 222.5 kb | Distal (>10kb) Multiome | 281 | |
| chr1:201,399,066–201,399,918 | 245.0 kb | Distal (>10kb) Multiome | 592 | |
| chr1:201,408,123–201,408,690 | 253.9 kb | Distal (>10kb) Multiome | 297 | |
| chr1:201,448,161–201,448,846 | 293.9 kb | Distal (>10kb) Multiome | 392 |
Genomic view of the TMEM9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.