Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM74B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM74B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM74B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:884,981–885,530 | 300.2 kb | Distal (>10kb) Multiome | 183 | |
| chr20:955,007–955,547 | 230.1 kb | Distal (>10kb) Multiome | 24 | |
| chr20:1,001,978–1,002,815 | 183.0 kb | Distal (>10kb) Multiome | 124 | |
| chr20:1,061,388–1,061,918 | 123.8 kb | Distal (>10kb) Multiome | 105 | |
| chr20:1,118,327–1,119,071 | 66.8 kb | Distal (>10kb) Multiome | 1066 | |
| chr20:1,184,818–1,186,197 | 366 bp | At TSS Multiome | 557 | |
| chr20:1,186,736–1,187,055 | 1.3 kb | Proximal (<10kb) | 128 | |
| chr20:1,225,365–1,226,806 | 40.4 kb | Distal (>10kb) Multiome | 616 | |
| chr20:1,266,029–1,266,958 | 81.0 kb | Distal (>10kb) Multiome | 499 | |
| chr20:1,300,911–1,301,500 | 115.9 kb | Distal (>10kb) Multiome | 171 | |
| chr20:1,313,163–1,313,790 | 128.1 kb | Distal (>10kb) Multiome | 428 | |
| chr20:1,325,008–1,326,107 | 140.0 kb | Distal (>10kb) Multiome | 901 | |
| chr20:1,392,628–1,393,457 | 207.7 kb | Distal (>10kb) Multiome | 799 | |
| chr20:1,427,438–1,428,145 | 242.4 kb | Distal (>10kb) Multiome | 285 | |
| chr20:1,466,316–1,467,471 | 281.5 kb | Distal (>10kb) Multiome | 1054 |
Genomic view of the TMEM74B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.