TMEM63B
transmembrane protein 63B | DKFZp434P0531, dJ421H19.2, C6orf110

Enables mechanosensitive monoatomic cation channel activity. Predicted to be involved in sensory perception of sound and surfactant secretion. Located in actin cytoskeleton; cytoplasmic vesicle membrane; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

Developmental clusters: GC6
Biological processes 41 terms
actin cytoskeleton (GO:0015629)alveolar lamellar body membrane (GO:0097233)calcium-activated cation channel activity (GO:0005227)calcium-activated cation channel activity (GO:0005227)calcium-activated cation channel activity (GO:0005227)calcium-activated cation channel activity (GO:0005227)drinking behavior (GO:0042756)drinking behavior (GO:0042756)early endosome membrane (GO:0031901)early endosome membrane (GO:0031901)endoplasmic reticulum membrane (GO:0005789)intestinal stem cell homeostasis (GO:0036335)intestinal stem cell homeostasis (GO:0036335)lysosomal membrane (GO:0005765)lysosomal membrane (GO:0005765)mechanosensitive monoatomic cation channel activity (GO:0140135)mechanosensitive monoatomic ion channel activity (GO:0008381)mechanosensitive monoatomic ion channel activity (GO:0008381)mechanosensitive monoatomic ion channel activity (GO:0008381)membrane (GO:0016020)monoatomic cation transmembrane transport (GO:0098655)monoatomic ion transmembrane transport (GO:0034220)osmolarity-sensing monoatomic cation channel activity (GO:1990760)osmolarity-sensing monoatomic cation channel activity (GO:1990760)phosphatidylcholine transfer activity (GO:0120019)phosphatidylcholine transfer activity (GO:0120019)phospholipid scramblase activity (GO:0017128)phospholipid scramblase activity (GO:0017128)phospholipid scramblase activity (GO:0017128)phospholipid transport (GO:0015914)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane phospholipid scrambling (GO:0017121)sensory perception of sound (GO:0007605)sensory perception of sound (GO:0007605)sphingomyelin transfer activity (GO:0140338)sphingomyelin transfer activity (GO:0140338)surfactant secretion (GO:0160069)surfactant secretion (GO:0160069)
Expression (TPM)
TMEM63B — as a Regulated Gene

TFs regulating TMEM63B 0 TFs

Transcription factors with Perturb-seq knockdown data for TMEM63B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM63B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to TMEM63B

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM63B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr6:43,926,273–43,928,465 200.4 kb Distal (>10kb) Multiome 1000
chr6:43,951,107–43,951,921 176.2 kb Distal (>10kb) Multiome 591
chr6:44,002,061–44,003,708 124.9 kb Distal (>10kb) Multiome 581
chr6:44,126,767–44,128,943 135 bp At TSS Multiome 845
chr6:44,151,741–44,152,312 24.4 kb Distal (>10kb) Multiome 575
chr6:44,185,920–44,186,571 58.6 kb Distal (>10kb) Multiome 95
chr6:44,202,490–44,203,242 75.2 kb Distal (>10kb) Multiome 229
chr6:44,216,763–44,217,285 89.4 kb Distal (>10kb) Multiome 139
chr6:44,218,945–44,220,120 91.9 kb Distal (>10kb) Multiome 799
chr6:44,223,166–44,224,465 96.0 kb Distal (>10kb) Multiome 783
chr6:44,234,203–44,235,350 107.2 kb Distal (>10kb) Multiome 499
chr6:44,237,380–44,238,386 110.3 kb Distal (>10kb) Multiome 969
chr6:44,245,610–44,248,192 120.4 kb Distal (>10kb) Multiome 1271
chr6:44,256,209–44,258,064 129.8 kb Distal (>10kb) Multiome 1042
chr6:44,264,892–44,265,788 137.9 kb Distal (>10kb) Multiome 760
chr6:44,270,373–44,271,349 143.4 kb Distal (>10kb) Multiome 166
chr6:44,275,626–44,276,572 148.4 kb Distal (>10kb) Multiome 330
chr6:44,297,234–44,298,035 170.1 kb Distal (>10kb) Multiome 356
chr6:44,312,866–44,313,523 185.6 kb Distal (>10kb) Multiome 1073
chr6:44,342,481–44,342,962 215.1 kb Distal (>10kb) Multiome 133
chr6:44,387,185–44,388,395 260.0 kb Distal (>10kb) Multiome 955

Genome Browser

Genomic view of the TMEM63B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr6:43,916,273 – 44,398,395
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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