This gene encodes a predicted type-I membrane glycoprotein. The encoded protein may play a role in functioning of the central nervous system. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TMEM59L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM59L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM59L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:18,322,635–18,323,493 | 289.7 kb | Distal (>10kb) Multiome | 814 | |
| chr19:18,328,417–18,328,936 | 284.3 kb | Distal (>10kb) Multiome | 488 | |
| chr19:18,340,428–18,341,393 | 272.3 kb | Distal (>10kb) Multiome | 747 | |
| chr19:18,373,917–18,374,961 | 238.3 kb | Distal (>10kb) Multiome | 971 | |
| chr19:18,416,224–18,418,189 | 195.2 kb | Distal (>10kb) Multiome | 893 | |
| chr19:18,418,296–18,420,432 | 193.5 kb | Distal (>10kb) Multiome | 773 | |
| chr19:18,428,554–18,429,777 | 183.7 kb | Distal (>10kb) Multiome | 489 | |
| chr19:18,433,114–18,434,328 | 178.8 kb | Distal (>10kb) Multiome | 446 | |
| chr19:18,436,634–18,439,166 | 174.6 kb | Distal (>10kb) Multiome | 799 | |
| chr19:18,521,058–18,522,859 | 90.5 kb | Distal (>10kb) Multiome | 849 | |
| chr19:18,543,118–18,544,249 | 69.2 kb | Distal (>10kb) Multiome | 574 | |
| chr19:18,557,570–18,558,196 | 55.1 kb | Distal (>10kb) Multiome | 738 | |
| chr19:18,571,234–18,572,258 | 41.2 kb | Distal (>10kb) Multiome | 972 | |
| chr19:18,588,272–18,591,023 | 22.3 kb | Distal (>10kb) Multiome | 1174 | |
| chr19:18,593,729–18,595,402 | 18.5 kb | Distal (>10kb) Multiome | 464 | |
| chr19:18,603,512–18,604,241 | 8.6 kb | Proximal (<10kb) | 161 | |
| chr19:18,606,608–18,607,085 | 5.8 kb | Proximal (<10kb) | 100 | |
| chr19:18,610,441–18,611,114 | 1.8 kb | Proximal (<10kb) | 470 | |
| chr19:18,611,391–18,612,134 | 1.1 kb | Proximal (<10kb) Multiome | 340 | |
| chr19:18,635,894–18,637,555 | 23.7 kb | Distal (>10kb) Multiome | 617 | |
| chr19:18,682,925–18,684,360 | 70.8 kb | Distal (>10kb) Multiome | 701 | |
| chr19:18,785,146–18,785,600 | 172.5 kb | Distal (>10kb) Multiome | 247 | |
| chr19:18,831,386–18,833,070 | 219.0 kb | Distal (>10kb) Multiome | 833 | |
| chr19:18,870,063–18,870,526 | 257.6 kb | Distal (>10kb) Multiome | 148 | |
| chr19:18,895,036–18,896,591 | 283.2 kb | Distal (>10kb) Multiome | 554 |
Genomic view of the TMEM59L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.