TMEM59

transmembrane protein 59 | HSPC001, C1orf8

This gene encodes a protein shown to regulate autophagy in response to bacterial infection. This protein may also regulate the retention of amyloid precursor protein (APP) in the Golgi apparatus through its control of APP glycosylation. Overexpression of this protein has been found to promote apoptosis in a glioma cell line. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

Member of: DE-1 DE-1.11 Developmental clusters: GC5

Biological processes 18 terms

Golgi cis cisterna (GO:0000137)Golgi medial cisterna (GO:0005797)Golgi membrane (GO:0000139)Golgi trans cisterna (GO:0000138)endopeptidase activity (GO:0004175)extracellular exosome (GO:0070062)glycoprotein biosynthetic process (GO:0009101)late endosome (GO:0005770)late endosome (GO:0005770)late endosome membrane (GO:0031902)lysosomal membrane (GO:0005765)lysosome (GO:0005764)lysosome (GO:0005764)negative regulation of protein localization to plasma membrane (GO:1903077)plasma membrane (GO:0005886)positive regulation of autophagy (GO:0010508)positive regulation of autophagy (GO:0010508)protein binding (GO:0005515)

Expression (TPM)

TFs regulating TMEM59 0 TFs

Transcription factors with Perturb-seq knockdown data for TMEM59. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM59 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to TMEM59

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM59, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr1:53,838,019–53,838,779	215.0 kb	Distal (>10kb) Multiome	1058
chr1:53,889,527–53,890,054	163.6 kb	Distal (>10kb) Multiome	654
chr1:53,944,886–53,946,958	107.5 kb	Distal (>10kb) Multiome	806
chr1:53,956,851–53,957,534	96.2 kb	Distal (>10kb) Multiome	255
chr1:54,052,651–54,054,132	6 bp	At TSS Multiome	833
chr1:54,121,133–54,122,207	68.2 kb	Distal (>10kb) Multiome	490
chr1:54,199,512–54,200,664	146.7 kb	Distal (>10kb) Multiome	741
chr1:54,800,637–54,801,431	747.8 kb	Distal (>10kb) Multiome HiCAR	286

Genome Browser

Genomic view of the TMEM59 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.