Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM51. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM51 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM51, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:14,923,758–14,925,612 | 227.3 kb | Distal (>10kb) Multiome | 443 | |
| chr1:15,139,767–15,140,647 | 12.5 kb | Distal (>10kb) Multiome | 554 | |
| chr1:15,152,399–15,154,344 | 1.2 kb | Proximal (<10kb) Multiome | 772 | |
| chr1:15,154,564–15,155,000 | 2.0 kb | Proximal (<10kb) | 197 | |
| chr1:15,157,137–15,157,352 | 4.6 kb | Proximal (<10kb) | 20 | |
| chr1:15,196,898–15,197,476 | 44.6 kb | Distal (>10kb) Multiome HiCAR | 173 | |
| chr1:15,246,891–15,247,752 | 94.8 kb | Distal (>10kb) Multiome HiCAR | 362 | |
| chr1:15,409,150–15,410,227 | 257.2 kb | Distal (>10kb) Multiome | 618 | |
| chr1:15,412,068–15,412,674 | 259.8 kb | Distal (>10kb) Multiome | 120 |
Genomic view of the TMEM51 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.