Enables phospholipid scramblase activity. Involved in autophagosome assembly and intracellular lipid transport. Located in mitochondria-associated endoplasmic reticulum membrane contact site. Is active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM41B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM41B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM41B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:9,090,882–9,091,926 | 223.1 kb | Distal (>10kb) Multiome | 196 | |
| chr11:9,264,697–9,266,230 | 49.2 kb | Distal (>10kb) Multiome | 703 | |
| chr11:9,313,980–9,315,407 | 79 bp | At TSS Multiome | 997 | |
| chr11:9,318,649–9,319,624 | 4.7 kb | Proximal (<10kb) Multiome | 258 | |
| chr11:9,363,967–9,364,851 | 49.9 kb | Distal (>10kb) Multiome | 1019 | |
| chr11:9,384,450–9,385,531 | 70.0 kb | Distal (>10kb) Multiome | 939 | |
| chr11:9,460,209–9,461,643 | 146.3 kb | Distal (>10kb) Multiome | 1040 | |
| chr11:9,572,794–9,575,580 | 260.7 kb | Distal (>10kb) Multiome | 1075 | |
| chr11:9,613,193–9,614,617 | 299.5 kb | Distal (>10kb) Multiome | 997 |
Genomic view of the TMEM41B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.