Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM41A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM41A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM41A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:185,249,926–185,250,485 | 248.9 kb | Distal (>10kb) Multiome | 51 | |
| chr3:185,267,961–185,268,947 | 230.5 kb | Distal (>10kb) Multiome | 258 | |
| chr3:185,269,944–185,270,809 | 228.4 kb | Distal (>10kb) Multiome | 180 | |
| chr3:185,282,769–185,283,294 | 216.0 kb | Distal (>10kb) Multiome | 660 | |
| chr3:185,372,493–185,373,188 | 126.3 kb | Distal (>10kb) Multiome | 60 | |
| chr3:185,498,399–185,499,479 | 40 bp | At TSS Multiome | 1024 | |
| chr3:185,581,887–185,582,879 | 83.3 kb | Distal (>10kb) Multiome | 125 | |
| chr3:185,585,767–185,586,789 | 87.2 kb | Distal (>10kb) Multiome | 851 | |
| chr3:185,786,185–185,786,786 | 287.5 kb | Distal (>10kb) Multiome | 166 |
Genomic view of the TMEM41A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.