Involved in positive regulation of endoplasmic reticulum unfolded protein response; regulation of endoplasmic reticulum tubular network organization; and response to endoplasmic reticulum stress. Located in endoplasmic reticulum membrane; melanosome; and nuclear envelope. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM33. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM33 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM33, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:41,644,230–41,644,895 | 290.7 kb | Distal (>10kb) Multiome | 292 | |
| chr4:41,750,881–41,752,090 | 183.8 kb | Distal (>10kb) Multiome | 140 | |
| chr4:41,866,914–41,867,668 | 67.8 kb | Distal (>10kb) Multiome | 127 | |
| chr4:41,880,210–41,881,871 | 54.4 kb | Distal (>10kb) Multiome | 107 | |
| chr4:41,934,796–41,935,930 | 134 bp | At TSS Multiome | 814 | |
| chr4:41,989,790–41,991,167 | 55.4 kb | Distal (>10kb) Multiome | 816 | |
| chr4:42,150,652–42,153,392 | 217.3 kb | Distal (>10kb) Multiome | 429 |
Genomic view of the TMEM33 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.