Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM267. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM267 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM267, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:43,191,656–43,192,908 | 291.7 kb | Distal (>10kb) Multiome | 475 | |
| chr5:43,312,549–43,314,340 | 170.2 kb | Distal (>10kb) Multiome | 954 | |
| chr5:43,348,196–43,348,656 | 135.5 kb | Distal (>10kb) Multiome | 141 | |
| chr5:43,396,804–43,397,322 | 86.7 kb | Distal (>10kb) Multiome | 340 | |
| chr5:43,416,225–43,416,784 | 67.4 kb | Distal (>10kb) Multiome | 263 | |
| chr5:43,483,333–43,484,741 | 69 bp | At TSS Multiome | 1033 | |
| chr5:43,514,568–43,515,502 | 31.3 kb | Distal (>10kb) Multiome | 817 | |
| chr5:43,555,878–43,557,718 | 73.1 kb | Distal (>10kb) Multiome | 936 | |
| chr5:43,602,369–43,604,281 | 119.3 kb | Distal (>10kb) Multiome | 912 |
Genomic view of the TMEM267 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.