Predicted to enable oligosaccharyltransferase complex binding activity. Involved in protein N-linked glycosylation. Located in endoplasmic reticulum and membrane. Part of oligosaccharyltransferase complex A and oligosaccharyltransferase complex B. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM258. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM258 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM258, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:61,508,087–61,510,095 | 284.0 kb | Distal (>10kb) Multiome | 740 | |
| chr11:61,567,110–61,568,033 | 225.0 kb | Distal (>10kb) Multiome | 1078 | |
| chr11:61,580,454–61,581,871 | 211.3 kb | Distal (>10kb) Multiome | 760 | |
| chr11:61,587,343–61,588,726 | 204.3 kb | Distal (>10kb) Multiome | 271 | |
| chr11:61,680,168–61,680,631 | 112.3 kb | Distal (>10kb) Multiome | 532 | |
| chr11:61,747,560–61,748,157 | 44.7 kb | Distal (>10kb) Multiome | 493 | |
| chr11:61,752,190–61,753,041 | 40.0 kb | Distal (>10kb) Multiome | 329 | |
| chr11:61,777,258–61,777,759 | 15.1 kb | Distal (>10kb) Multiome | 149 | |
| chr11:61,792,046–61,793,394 | 170 bp | At TSS Multiome | 896 | |
| chr11:61,814,541–61,817,407 | 22.7 kb | Distal (>10kb) Multiome | 1128 | |
| chr11:61,827,285–61,829,337 | 35.4 kb | Distal (>10kb) Multiome | 728 | |
| chr11:61,871,019–61,871,621 | 78.7 kb | Distal (>10kb) Multiome | 443 | |
| chr11:61,890,974–61,892,214 | 99.1 kb | Distal (>10kb) Multiome HiCAR | 619 | |
| chr11:61,898,986–61,899,424 | 106.7 kb | Distal (>10kb) Multiome | 498 | |
| chr11:61,917,152–61,917,983 | 125.0 kb | Distal (>10kb) Multiome | 465 | |
| chr11:61,955,466–61,956,219 | 163.2 kb | Distal (>10kb) Multiome | 217 | |
| chr11:61,966,654–61,968,718 | 175.1 kb | Distal (>10kb) Multiome | 939 | |
| chr11:61,971,541–61,972,360 | 179.4 kb | Distal (>10kb) Multiome | 877 |
Genomic view of the TMEM258 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.