Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM245. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM245 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM245, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:108,933,334–108,934,940 | 185.7 kb | Distal (>10kb) Multiome | 940 | |
| chr9:109,012,369–109,014,144 | 106.3 kb | Distal (>10kb) Multiome | 780 | |
| chr9:109,118,835–109,120,627 | 49 bp | At TSS Multiome | 832 | |
| chr9:109,124,131–109,124,369 | 4.2 kb | Proximal (<10kb) | 18 | |
| chr9:109,166,465–109,167,517 | 47.2 kb | Distal (>10kb) Multiome | 131 | |
| chr9:109,318,263–109,318,687 | 198.4 kb | Distal (>10kb) Multiome | 110 | |
| chr9:109,319,189–109,321,425 | 201.1 kb | Distal (>10kb) Multiome | 907 |
Genomic view of the TMEM245 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.