Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM234. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM234 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM234, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:31,937,587–31,938,944 | 283.9 kb | Distal (>10kb) Multiome | 1111 | |
| chr1:31,943,994–31,945,090 | 277.8 kb | Distal (>10kb) Multiome | 826 | |
| chr1:31,954,721–31,955,545 | 267.2 kb | Distal (>10kb) Multiome | 628 | |
| chr1:31,964,141–31,964,595 | 258.1 kb | Distal (>10kb) Multiome | 529 | |
| chr1:32,013,168–32,015,085 | 208.7 kb | Distal (>10kb) Multiome | 988 | |
| chr1:32,072,319–32,073,738 | 149.2 kb | Distal (>10kb) Multiome | 909 | |
| chr1:32,107,881–32,108,706 | 114.2 kb | Distal (>10kb) Multiome | 779 | |
| chr1:32,179,263–32,180,190 | 42.6 kb | Distal (>10kb) Multiome | 1019 | |
| chr1:32,200,233–32,201,756 | 21.7 kb | Distal (>10kb) Multiome | 573 | |
| chr1:32,204,985–32,206,258 | 16.8 kb | Distal (>10kb) Multiome | 679 | |
| chr1:32,215,716–32,215,931 | 6.4 kb | Proximal (<10kb) | 220 | |
| chr1:32,221,877–32,222,889 | 6 bp | At TSS Multiome | 755 | |
| chr1:32,239,728–32,240,979 | 18.0 kb | Distal (>10kb) Multiome | 456 | |
| chr1:32,248,081–32,248,895 | 26.1 kb | Distal (>10kb) Multiome | 622 | |
| chr1:32,291,710–32,292,726 | 69.7 kb | Distal (>10kb) Multiome | 900 | |
| chr1:32,334,713–32,336,836 | 113.9 kb | Distal (>10kb) Multiome | 804 | |
| chr1:32,351,055–32,352,355 | 129.2 kb | Distal (>10kb) Multiome | 944 | |
| chr1:32,361,365–32,362,459 | 139.8 kb | Distal (>10kb) Multiome | 305 | |
| chr1:32,393,928–32,395,356 | 172.3 kb | Distal (>10kb) Multiome | 930 | |
| chr1:32,437,702–32,438,502 | 215.9 kb | Distal (>10kb) Multiome | 85 | |
| chr1:32,439,697–32,440,223 | 217.6 kb | Distal (>10kb) Multiome | 40 | |
| chr1:32,464,697–32,465,552 | 242.7 kb | Distal (>10kb) Multiome | 408 | |
| chr1:32,500,363–32,501,049 | 278.4 kb | Distal (>10kb) Multiome | 540 | |
| chr1:32,520,498–32,520,989 | 298.4 kb | Distal (>10kb) Multiome | 384 |
Genomic view of the TMEM234 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.