Located in dendrite. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM222. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM222 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM222, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:27,031,351–27,031,956 | 290.5 kb | Distal (>10kb) Multiome | 260 | |
| chr1:27,102,589–27,103,140 | 219.4 kb | Distal (>10kb) Multiome HiCAR | 263 | |
| chr1:27,154,381–27,155,711 | 167.2 kb | Distal (>10kb) Multiome | 1038 | |
| chr1:27,233,894–27,235,362 | 87.8 kb | Distal (>10kb) Multiome | 807 | |
| chr1:27,321,904–27,322,688 | 117 bp | At TSS Multiome | 1013 | |
| chr1:27,349,161–27,350,366 | 27.5 kb | Distal (>10kb) Multiome | 573 | |
| chr1:27,350,548–27,351,814 | 29.0 kb | Distal (>10kb) Multiome | 387 | |
| chr1:27,357,379–27,358,028 | 35.4 kb | Distal (>10kb) Multiome | 449 | |
| chr1:27,360,338–27,361,256 | 38.3 kb | Distal (>10kb) Multiome | 170 | |
| chr1:27,365,152–27,367,350 | 44.6 kb | Distal (>10kb) Multiome | 748 | |
| chr1:27,382,910–27,383,795 | 61.1 kb | Distal (>10kb) Multiome | 234 | |
| chr1:27,391,473–27,393,056 | 70.3 kb | Distal (>10kb) Multiome | 700 | |
| chr1:27,489,673–27,490,714 | 168.0 kb | Distal (>10kb) Multiome | 978 | |
| chr1:27,526,947–27,528,904 | 205.1 kb | Distal (>10kb) Multiome | 804 | |
| chr1:27,536,779–27,537,308 | 214.7 kb | Distal (>10kb) Multiome | 160 | |
| chr1:27,556,820–27,557,711 | 235.0 kb | Distal (>10kb) Multiome | 511 | |
| chr1:27,568,200–27,569,231 | 246.3 kb | Distal (>10kb) Multiome | 554 | |
| chr1:27,574,996–27,576,410 | 253.8 kb | Distal (>10kb) Multiome | 587 | |
| chr1:27,592,703–27,593,619 | 270.8 kb | Distal (>10kb) Multiome | 100 | |
| chr1:27,602,169–27,605,005 | 281.9 kb | Distal (>10kb) Multiome HiCAR | 726 | |
| chr1:27,606,947–27,607,757 | 285.2 kb | Distal (>10kb) Multiome HiCAR | 620 | |
| chr1:27,614,890–27,615,294 | 292.8 kb | Distal (>10kb) Multiome | 84 |
Genomic view of the TMEM222 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.