Predicted to be located in cilium and membrane. Implicated in Joubert syndrome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM218. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM218 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM218, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:124,839,093–124,840,110 | 271.9 kb | Distal (>10kb) Multiome | 246 | |
| chr11:124,842,870–124,844,108 | 268.3 kb | Distal (>10kb) Multiome | 219 | |
| chr11:124,875,886–124,877,815 | 235.1 kb | Distal (>10kb) Multiome | 769 | |
| chr11:124,920,725–124,921,671 | 190.5 kb | Distal (>10kb) Multiome | 329 | |
| chr11:124,953,809–124,954,493 | 157.5 kb | Distal (>10kb) Multiome | 818 | |
| chr11:125,062,600–125,064,019 | 48.4 kb | Distal (>10kb) Multiome | 640 | |
| chr11:125,111,022–125,112,225 | 149 bp | At TSS Multiome | 651 | |
| chr11:125,114,641–125,114,813 | 3.0 kb | Proximal (<10kb) | 59 | |
| chr11:125,163,468–125,165,998 | 53.1 kb | Distal (>10kb) Multiome | 417 | |
| chr11:125,224,246–125,224,764 | 113.0 kb | Distal (>10kb) Multiome | 63 | |
| chr11:125,239,981–125,240,709 | 128.7 kb | Distal (>10kb) Multiome | 103 | |
| chr11:125,262,828–125,263,907 | 151.9 kb | Distal (>10kb) Multiome HiCAR | 339 | |
| chr11:125,330,306–125,331,087 | 219.2 kb | Distal (>10kb) Multiome | 104 | |
| chr11:125,369,857–125,372,110 | 258.6 kb | Distal (>10kb) Multiome HiCAR | 226 | |
| chr11:125,404,667–125,405,169 | 293.4 kb | Distal (>10kb) Multiome HiCAR | 273 |
Genomic view of the TMEM218 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.