This gene encodes a highly conserved protein which is localized in the endoplasmic reticulum (ER). The protein is linked to autophagy and ER stress. Knockdown of this gene increased autophagy and triggered ER stress. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Transcription factors with Perturb-seq knockdown data for TMEM208. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM208 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM208, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:66,933,957–66,934,849 | 292.7 kb | Distal (>10kb) Multiome | 931 | |
| chr16:67,000,412–67,001,423 | 226.1 kb | Distal (>10kb) Multiome HiCAR | 270 | |
| chr16:67,013,778–67,014,584 | 213.0 kb | Distal (>10kb) Multiome | 594 | |
| chr16:67,017,916–67,018,379 | 209.0 kb | Distal (>10kb) Multiome | 530 | |
| chr16:67,028,567–67,029,938 | 198.1 kb | Distal (>10kb) Multiome | 1003 | |
| chr16:67,109,102–67,110,434 | 117.3 kb | Distal (>10kb) Multiome | 895 | |
| chr16:67,149,282–67,151,406 | 76.4 kb | Distal (>10kb) Multiome | 693 | |
| chr16:67,154,687–67,155,820 | 71.7 kb | Distal (>10kb) Multiome | 593 | |
| chr16:67,160,628–67,161,206 | 66.1 kb | Distal (>10kb) Multiome | 524 | |
| chr16:67,162,969–67,163,815 | 63.7 kb | Distal (>10kb) Multiome | 238 | |
| chr16:67,169,105–67,171,287 | 57.6 kb | Distal (>10kb) Multiome | 813 | |
| chr16:67,173,849–67,174,861 | 52.8 kb | Distal (>10kb) Multiome | 809 | |
| chr16:67,177,863–67,178,664 | 48.9 kb | Distal (>10kb) Multiome | 544 | |
| chr16:67,183,333–67,184,856 | 43.3 kb | Distal (>10kb) Multiome | 886 | |
| chr16:67,185,256–67,185,693 | 41.6 kb | Distal (>10kb) Multiome | 740 | |
| chr16:67,191,949–67,192,449 | 35.0 kb | Distal (>10kb) Multiome | 781 | |
| chr16:67,198,940–67,200,211 | 27.4 kb | Distal (>10kb) Multiome | 325 | |
| chr16:67,226,487–67,227,575 | 125 bp | At TSS Multiome | 909 | |
| chr16:67,236,439–67,237,267 | 9.6 kb | Proximal (<10kb) Multiome | 195 | |
| chr16:67,245,855–67,247,890 | 20.4 kb | Distal (>10kb) Multiome | 1077 | |
| chr16:67,248,206–67,249,338 | 21.9 kb | Distal (>10kb) Multiome | 467 | |
| chr16:67,262,177–67,262,869 | 35.3 kb | Distal (>10kb) Multiome | 24 | |
| chr16:67,278,724–67,279,792 | 52.3 kb | Distal (>10kb) Multiome | 869 | |
| chr16:67,326,413–67,327,343 | 99.7 kb | Distal (>10kb) Multiome | 585 | |
| chr16:67,393,199–67,393,789 | 166.4 kb | Distal (>10kb) Multiome | 377 | |
| chr16:67,396,006–67,396,718 | 169.3 kb | Distal (>10kb) Multiome | 375 | |
| chr16:67,399,230–67,399,872 | 172.4 kb | Distal (>10kb) Multiome | 211 | |
| chr16:67,415,996–67,416,812 | 189.3 kb | Distal (>10kb) Multiome | 687 | |
| chr16:67,428,012–67,428,783 | 201.2 kb | Distal (>10kb) Multiome | 382 | |
| chr16:67,430,407–67,432,610 | 204.0 kb | Distal (>10kb) Multiome | 790 | |
| chr16:67,480,508–67,481,841 | 254.1 kb | Distal (>10kb) Multiome | 1002 | |
| chr16:67,521,086–67,521,812 | 294.3 kb | Distal (>10kb) Multiome | 775 |
Genomic view of the TMEM208 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.