Predicted to enable actin filament binding activity and lamin binding activity. Involved in several processes, including centrosome localization; positive regulation of endothelial cell migration; and protein localization to nuclear envelope. Located in cortical endoplasmic reticulum; nuclear inner membrane; and spindle pole centrosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM201. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM201 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM201, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:9,292,267–9,293,831 | 296.1 kb | Distal (>10kb) Multiome | 521 | |
| chr1:9,319,794–9,320,541 | 268.7 kb | Distal (>10kb) Multiome | 91 | |
| chr1:9,374,739–9,375,309 | 213.9 kb | Distal (>10kb) Multiome | 121 | |
| chr1:9,428,560–9,429,575 | 159.9 kb | Distal (>10kb) Multiome | 815 | |
| chr1:9,495,048–9,495,686 | 93.5 kb | Distal (>10kb) Multiome | 606 | |
| chr1:9,538,797–9,540,343 | 49.5 kb | Distal (>10kb) Multiome | 879 | |
| chr1:9,588,272–9,589,797 | 206 bp | At TSS Multiome | 633 | |
| chr1:9,593,403–9,593,904 | 4.7 kb | Proximal (<10kb) Multiome | 326 | |
| chr1:9,627,002–9,627,511 | 38.3 kb | Distal (>10kb) Multiome | 773 | |
| chr1:9,651,631–9,652,549 | 63.2 kb | Distal (>10kb) Multiome | 373 | |
| chr1:9,687,158–9,688,089 | 98.7 kb | Distal (>10kb) Multiome | 575 | |
| chr1:9,688,950–9,690,301 | 100.6 kb | Distal (>10kb) Multiome | 585 | |
| chr1:9,823,213–9,824,739 | 235.2 kb | Distal (>10kb) Multiome | 652 | |
| chr1:9,874,956–9,875,558 | 286.2 kb | Distal (>10kb) Multiome | 397 |
Genomic view of the TMEM201 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.