Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM185B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM185B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM185B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:119,678,779–119,679,506 | 544.3 kb | Distal (>10kb) Multiome HiCAR | 786 | |
| chr2:119,759,053–119,760,696 | 463.6 kb | Distal (>10kb) Multiome HiCAR | 1033 | |
| chr2:119,996,816–119,997,661 | 226.2 kb | Distal (>10kb) Multiome | 20 | |
| chr2:120,012,388–120,013,831 | 210.4 kb | Distal (>10kb) Multiome | 973 | |
| chr2:120,216,352–120,216,602 | 6.8 kb | Proximal (<10kb) | 106 | |
| chr2:120,222,919–120,223,954 | 3 bp | At TSS Multiome | 806 | |
| chr2:120,227,253–120,227,806 | 3.9 kb | Proximal (<10kb) | 183 | |
| chr2:120,237,598–120,238,948 | 14.8 kb | Distal (>10kb) Multiome | 425 | |
| chr2:120,252,124–120,253,825 | 29.4 kb | Distal (>10kb) Multiome | 912 | |
| chr2:120,343,217–120,343,961 | 120.2 kb | Distal (>10kb) Multiome | 453 | |
| chr2:120,441,791–120,443,631 | 219.8 kb | Distal (>10kb) Multiome | 511 | |
| chr2:120,465,595–120,466,904 | 242.9 kb | Distal (>10kb) Multiome | 829 |
Genomic view of the TMEM185B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.