Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM184B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM184B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM184B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:37,983,021–37,985,110 | 288.6 kb | Distal (>10kb) Multiome | 228 | |
| chr22:38,052,312–38,052,803 | 220.5 kb | Distal (>10kb) Multiome | 529 | |
| chr22:38,057,008–38,057,702 | 215.7 kb | Distal (>10kb) Multiome | 656 | |
| chr22:38,080,912–38,081,618 | 191.9 kb | Distal (>10kb) Multiome | 175 | |
| chr22:38,097,697–38,098,236 | 175.1 kb | Distal (>10kb) Multiome | 186 | |
| chr22:38,181,365–38,182,291 | 91.1 kb | Distal (>10kb) Multiome | 676 | |
| chr22:38,201,378–38,203,636 | 71.1 kb | Distal (>10kb) Multiome | 848 | |
| chr22:38,214,397–38,215,017 | 58.2 kb | Distal (>10kb) Multiome | 382 | |
| chr22:38,272,379–38,273,237 | 27 bp | At TSS Multiome | 526 | |
| chr22:38,278,885–38,279,066 | 5.9 kb | Proximal (<10kb) | 116 | |
| chr22:38,317,171–38,317,940 | 44.4 kb | Distal (>10kb) Multiome | 524 | |
| chr22:38,319,024–38,319,874 | 46.6 kb | Distal (>10kb) Multiome | 181 | |
| chr22:38,335,940–38,336,726 | 63.2 kb | Distal (>10kb) Multiome | 297 | |
| chr22:38,353,217–38,354,166 | 80.4 kb | Distal (>10kb) Multiome | 404 | |
| chr22:38,397,757–38,399,352 | 126.0 kb | Distal (>10kb) Multiome | 345 | |
| chr22:38,455,555–38,456,345 | 183.1 kb | Distal (>10kb) Multiome | 403 | |
| chr22:38,461,291–38,461,848 | 188.7 kb | Distal (>10kb) Multiome | 595 | |
| chr22:38,505,466–38,506,961 | 233.5 kb | Distal (>10kb) Multiome | 889 | |
| chr22:38,569,664–38,571,256 | 297.3 kb | Distal (>10kb) Multiome | 559 |
Genomic view of the TMEM184B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.