Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM177. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM177 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM177, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:119,431,298–119,432,803 | 247.4 kb | Distal (>10kb) Multiome | 903 | |
| chr2:119,476,117–119,476,795 | 202.7 kb | Distal (>10kb) Multiome | 482 | |
| chr2:119,523,786–119,524,663 | 154.9 kb | Distal (>10kb) Multiome | 187 | |
| chr2:119,537,405–119,538,283 | 141.3 kb | Distal (>10kb) Multiome | 122 | |
| chr2:119,544,074–119,545,082 | 134.8 kb | Distal (>10kb) Multiome | 610 | |
| chr2:119,672,585–119,672,728 | 6.4 kb | Proximal (<10kb) | 23 | |
| chr2:119,678,779–119,679,506 | 28 bp | At TSS Multiome | 786 | |
| chr2:119,679,936–119,680,308 | 770 bp | At TSS | 38 | |
| chr2:119,700,871–119,701,304 | 22.0 kb | Distal (>10kb) Multiome | 92 | |
| chr2:119,702,889–119,703,364 | 23.9 kb | Distal (>10kb) Multiome | 436 | |
| chr2:119,759,053–119,760,696 | 80.6 kb | Distal (>10kb) Multiome | 1033 | |
| chr2:119,792,781–119,793,257 | 113.9 kb | Distal (>10kb) Multiome | 152 | |
| chr2:120,222,919–120,223,954 | 544.2 kb | Distal (>10kb) Multiome HiCAR | 806 |
Genomic view of the TMEM177 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.