This gene encodes a transmembrane protein component of a mechanosensitve ion channel that is activated by mechanical stimuli in various cell types and confers slowly adapting, mechanically activated currents in dorsal root ganglion neurons. Mechanically activated ion channels are sensors that are critical for hearing, touch, pain, and blood pressure regulation. [provided by RefSeq, Jul 2017]
Transcription factors with Perturb-seq knockdown data for TMEM150C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM150C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM150C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:82,284,318–82,285,814 | 276.9 kb | Distal (>10kb) Multiome | 566 | |
| chr4:82,372,612–82,374,867 | 187.7 kb | Distal (>10kb) Multiome | 1174 | |
| chr4:82,428,720–82,431,310 | 131.5 kb | Distal (>10kb) Multiome | 1120 | |
| chr4:82,561,307–82,562,355 | 69 bp | At TSS Multiome | 327 | |
| chr4:82,667,793–82,668,466 | 106.2 kb | Distal (>10kb) Multiome | 123 | |
| chr4:82,716,050–82,716,644 | 154.4 kb | Distal (>10kb) Multiome | 173 | |
| chr4:82,739,190–82,739,774 | 177.5 kb | Distal (>10kb) Multiome HiCAR | 317 | |
| chr4:82,797,244–82,798,074 | 235.5 kb | Distal (>10kb) Multiome | 243 | |
| chr4:82,798,169–82,799,103 | 236.8 kb | Distal (>10kb) Multiome | 368 |
Genomic view of the TMEM150C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.