Predicted to be involved in regulation of heme biosynthetic process. Predicted to act upstream of or within erythrocyte differentiation; mitochondrial transport; and nitrogen compound transport. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for TMEM14C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM14C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM14C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:10,487,538–10,488,562 | 235.1 kb | Distal (>10kb) Multiome | 115 | |
| chr6:10,520,974–10,521,572 | 201.8 kb | Distal (>10kb) Multiome | 516 | |
| chr6:10,555,376–10,556,448 | 167.2 kb | Distal (>10kb) Multiome | 264 | |
| chr6:10,582,607–10,584,703 | 140.0 kb | Distal (>10kb) Multiome HiCAR | 306 | |
| chr6:10,585,189–10,585,988 | 137.4 kb | Distal (>10kb) Multiome | 131 | |
| chr6:10,659,291–10,660,431 | 63.2 kb | Distal (>10kb) Multiome | 202 | |
| chr6:10,694,307–10,695,190 | 28.3 kb | Distal (>10kb) Multiome | 980 | |
| chr6:10,722,577–10,723,508 | 88 bp | At TSS Multiome | 960 | |
| chr6:10,726,962–10,727,214 | 3.9 kb | Proximal (<10kb) | 51 | |
| chr6:10,747,079–10,748,260 | 24.6 kb | Distal (>10kb) Multiome | 1006 | |
| chr6:10,837,383–10,838,947 | 115.4 kb | Distal (>10kb) Multiome | 773 | |
| chr6:10,882,510–10,883,313 | 159.9 kb | Distal (>10kb) Multiome | 144 | |
| chr6:10,886,419–10,887,541 | 163.9 kb | Distal (>10kb) Multiome | 615 | |
| chr6:11,007,370–11,008,733 | 285.0 kb | Distal (>10kb) Multiome | 412 |
Genomic view of the TMEM14C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.