Enables identical protein binding activity. Involved in cerebral cortex development; neural precursor cell proliferation; and regulation of G1/S transition of mitotic cell cycle. Predicted to be located in membrane. Predicted to be active in mitochondrial membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM14B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM14B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM14B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:10,487,538–10,488,562 | 259.8 kb | Distal (>10kb) Multiome | 115 | |
| chr6:10,520,974–10,521,572 | 226.5 kb | Distal (>10kb) Multiome | 516 | |
| chr6:10,555,376–10,556,448 | 191.9 kb | Distal (>10kb) Multiome | 264 | |
| chr6:10,582,607–10,584,703 | 164.7 kb | Distal (>10kb) Multiome | 306 | |
| chr6:10,585,189–10,585,988 | 162.1 kb | Distal (>10kb) Multiome | 131 | |
| chr6:10,659,291–10,660,431 | 87.9 kb | Distal (>10kb) Multiome | 202 | |
| chr6:10,694,307–10,695,190 | 53.0 kb | Distal (>10kb) Multiome | 980 | |
| chr6:10,722,577–10,723,508 | 24.8 kb | Distal (>10kb) Multiome | 960 | |
| chr6:10,747,079–10,748,260 | 110 bp | At TSS Multiome | 1006 | |
| chr6:10,748,641–10,749,211 | 883 bp | At TSS | 33 | |
| chr6:10,749,754–10,750,903 | 2.0 kb | Proximal (<10kb) | 259 | |
| chr6:10,751,820–10,752,338 | 4.1 kb | Proximal (<10kb) | 6 | |
| chr6:10,837,383–10,838,947 | 90.7 kb | Distal (>10kb) Multiome | 773 | |
| chr6:10,882,510–10,883,313 | 135.2 kb | Distal (>10kb) Multiome | 144 | |
| chr6:10,886,419–10,887,541 | 139.2 kb | Distal (>10kb) Multiome | 615 | |
| chr6:11,007,370–11,008,733 | 260.3 kb | Distal (>10kb) Multiome | 412 | |
| chr6:11,043,323–11,045,047 | 296.7 kb | Distal (>10kb) Multiome | 766 |
Genomic view of the TMEM14B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.