Enables ribosome binding activity. Involved in multi-pass transmembrane protein insertion into ER membrane and protein localization to nuclear inner membrane. Located in nuclear membrane. Part of multi-pass translocon complex. Is active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM147. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM147 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM147, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:35,247,580–35,249,688 | 296.9 kb | Distal (>10kb) Multiome | 1088 | |
| chr19:35,266,852–35,270,128 | 275.9 kb | Distal (>10kb) Multiome | 869 | |
| chr19:35,471,034–35,471,539 | 74.3 kb | Distal (>10kb) Multiome | 15 | |
| chr19:35,509,786–35,510,900 | 35.1 kb | Distal (>10kb) Multiome | 650 | |
| chr19:35,545,067–35,546,126 | 13 bp | At TSS Multiome | 879 | |
| chr19:35,549,256–35,549,470 | 3.6 kb | Proximal (<10kb) | 170 | |
| chr19:35,557,343–35,558,684 | 12.5 kb | Distal (>10kb) Multiome | 452 | |
| chr19:35,612,546–35,613,176 | 67.1 kb | Distal (>10kb) Multiome | 778 | |
| chr19:35,628,465–35,629,474 | 83.3 kb | Distal (>10kb) Multiome | 889 | |
| chr19:35,641,602–35,642,192 | 96.1 kb | Distal (>10kb) Multiome | 183 | |
| chr19:35,643,064–35,645,730 | 97.9 kb | Distal (>10kb) Multiome | 1010 | |
| chr19:35,648,040–35,648,575 | 102.6 kb | Distal (>10kb) Multiome | 599 | |
| chr19:35,673,179–35,673,643 | 127.8 kb | Distal (>10kb) Multiome | 311 | |
| chr19:35,702,152–35,702,985 | 156.9 kb | Distal (>10kb) Multiome | 662 | |
| chr19:35,716,025–35,718,811 | 172.1 kb | Distal (>10kb) Multiome | 1018 | |
| chr19:35,740,083–35,741,430 | 195.2 kb | Distal (>10kb) Multiome | 829 | |
| chr19:35,744,481–35,746,086 | 199.7 kb | Distal (>10kb) Multiome | 679 | |
| chr19:35,748,170–35,749,017 | 202.8 kb | Distal (>10kb) Multiome | 749 | |
| chr19:35,757,432–35,758,657 | 212.5 kb | Distal (>10kb) Multiome | 851 | |
| chr19:35,767,601–35,768,256 | 222.3 kb | Distal (>10kb) Multiome | 276 | |
| chr19:35,775,066–35,776,063 | 229.8 kb | Distal (>10kb) Multiome | 474 | |
| chr19:35,784,357–35,785,306 | 239.1 kb | Distal (>10kb) Multiome | 183 |
Genomic view of the TMEM147 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.