Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM132D. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM132D upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM132D, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:128,266,463–128,268,695 | 1637.0 kb | Distal (>10kb) Multiome HiCAR | 201 | |
| chr12:128,823,117–128,824,931 | 1080.0 kb | Distal (>10kb) Multiome HiCAR | 840 | |
| chr12:128,853,166–128,854,788 | 1049.8 kb | Distal (>10kb) Multiome HiCAR | 293 | |
| chr12:128,856,024–128,856,722 | 1047.7 kb | Distal (>10kb) Multiome HiCAR | 116 | |
| chr12:128,858,379–128,859,438 | 1045.1 kb | Distal (>10kb) Multiome HiCAR | 60 | |
| chr12:128,969,259–128,970,072 | 934.4 kb | Distal (>10kb) Multiome HiCAR | 192 | |
| chr12:129,163,411–129,164,328 | 740.2 kb | Distal (>10kb) Multiome HiCAR | 64 | |
| chr12:129,771,342–129,771,817 | 132.5 kb | Distal (>10kb) Multiome | 57 | |
| chr12:129,871,727–129,873,060 | 31.7 kb | Distal (>10kb) Multiome | 258 | |
| chr12:129,902,870–129,904,853 | 264 bp | At TSS Multiome | 260 | |
| chr12:129,911,510–129,911,757 | 7.5 kb | Proximal (<10kb) | 142 | |
| chr12:130,013,812–130,014,266 | 110.1 kb | Distal (>10kb) Multiome | 158 | |
| chr12:130,044,614–130,045,702 | 141.2 kb | Distal (>10kb) Multiome | 347 | |
| chr12:130,161,126–130,163,969 | 258.4 kb | Distal (>10kb) Multiome | 308 |
Genomic view of the TMEM132D locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.