Enables collagen binding activity. Involved in collagen biosynthetic process. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM131. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM131 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM131, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:97,711,706–97,712,616 | 283.7 kb | Distal (>10kb) Multiome | 160 | |
| chr2:97,931,591–97,932,156 | 64.0 kb | Distal (>10kb) Multiome | 81 | |
| chr2:97,935,884–97,936,533 | 59.7 kb | Distal (>10kb) Multiome | 427 | |
| chr2:97,995,175–97,996,676 | 184 bp | At TSS Multiome | 966 | |
| chr2:98,034,568–98,035,071 | 38.9 kb | Distal (>10kb) Multiome | 92 | |
| chr2:98,042,909–98,043,678 | 47.4 kb | Distal (>10kb) Multiome | 100 | |
| chr2:98,086,500–98,087,632 | 91.1 kb | Distal (>10kb) Multiome | 370 |
Genomic view of the TMEM131 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.