Predicted to be involved in signal transduction. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM116. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM116 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM116, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:111,766,539–111,767,436 | 246.3 kb | Distal (>10kb) Multiome | 732 | |
| chr12:111,775,668–111,776,178 | 237.2 kb | Distal (>10kb) Multiome | 448 | |
| chr12:111,841,636–111,842,766 | 171.1 kb | Distal (>10kb) Multiome | 963 | |
| chr12:111,967,710–111,968,344 | 45.1 kb | Distal (>10kb) Multiome HiCAR | 26 | |
| chr12:112,005,966–112,006,175 | 7.0 kb | Proximal (<10kb) | 202 | |
| chr12:112,012,418–112,014,496 | 111 bp | At TSS Multiome | 1077 | |
| chr12:112,108,135–112,109,541 | 95.6 kb | Distal (>10kb) Multiome | 788 | |
| chr12:112,116,420–112,116,883 | 103.5 kb | Distal (>10kb) Multiome | 549 | |
| chr12:112,125,273–112,125,989 | 112.3 kb | Distal (>10kb) Multiome | 798 |
Genomic view of the TMEM116 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.