Enables 14-3-3 protein binding activity and identical protein binding activity. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMCC3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMCC3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMCC3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:94,389,628–94,390,387 | 260.6 kb | Distal (>10kb) Multiome | 205 | |
| chr12:94,459,523–94,460,634 | 190.6 kb | Distal (>10kb) Multiome | 909 | |
| chr12:94,497,980–94,499,094 | 151.8 kb | Distal (>10kb) Multiome | 143 | |
| chr12:94,560,633–94,561,227 | 89.6 kb | Distal (>10kb) Multiome | 348 | |
| chr12:94,590,255–94,590,865 | 60.0 kb | Distal (>10kb) Multiome | 158 | |
| chr12:94,616,266–94,616,971 | 34.0 kb | Distal (>10kb) Multiome | 273 | |
| chr12:94,649,419–94,650,769 | 100 bp | At TSS Multiome | 452 | |
| chr12:94,731,827–94,732,454 | 81.6 kb | Distal (>10kb) Multiome | 96 | |
| chr12:94,815,972–94,816,516 | 165.6 kb | Distal (>10kb) Multiome | 183 | |
| chr12:94,872,875–94,874,146 | 223.1 kb | Distal (>10kb) Multiome | 358 |
Genomic view of the TMCC3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.