Enables preribosome binding activity. Involved in ribosomal large subunit biogenesis. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMA16. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMA16 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMA16, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:163,331,418–163,333,442 | 161.9 kb | Distal (>10kb) Multiome | 499 | |
| chr4:163,343,270–163,344,825 | 150.6 kb | Distal (>10kb) Multiome | 372 | |
| chr4:163,484,907–163,485,501 | 9.2 kb | Proximal (<10kb) | 166 | |
| chr4:163,493,027–163,493,317 | 1.3 kb | Proximal (<10kb) | 39 | |
| chr4:163,494,131–163,495,481 | 21 bp | At TSS Multiome | 1094 |
Genomic view of the TMA16 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.