Predicted to be involved in protein localization to membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TM9SF3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TM9SF3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TM9SF3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:96,309,703–96,310,258 | 277.0 kb | Distal (>10kb) Multiome | 187 | |
| chr10:96,324,253–96,324,992 | 262.4 kb | Distal (>10kb) Multiome | 66 | |
| chr10:96,375,112–96,375,818 | 211.6 kb | Distal (>10kb) Multiome | 477 | |
| chr10:96,513,081–96,514,568 | 73.1 kb | Distal (>10kb) Multiome | 703 | |
| chr10:96,579,949–96,580,368 | 6.6 kb | Proximal (<10kb) | 187 | |
| chr10:96,586,308–96,587,486 | 35 bp | At TSS Multiome | 840 | |
| chr10:96,719,871–96,720,167 | 133.1 kb | Distal (>10kb) Multiome | 395 | |
| chr10:96,720,285–96,721,494 | 133.8 kb | Distal (>10kb) Multiome | 522 | |
| chr10:96,831,710–96,834,047 | 245.5 kb | Distal (>10kb) Multiome | 859 |
Genomic view of the TM9SF3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.