The protein encoded by this gene contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily. This protein has sequence and structural similarities to the beta-amyloid binding protein (BBP), but, unlike BBP, it does not regulate a response to beta-amyloid peptide. This protein may have regulatory roles in cell death or proliferation signal cascades. This gene has multiple alternatively spliced transcript variants which encode two different isoforms. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TM2D2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TM2D2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TM2D2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:38,704,269–38,704,886 | 292.0 kb | Distal (>10kb) Multiome | 37 | |
| chr8:38,734,447–38,735,152 | 261.7 kb | Distal (>10kb) Multiome | 738 | |
| chr8:38,756,730–38,757,722 | 239.5 kb | Distal (>10kb) Multiome | 535 | |
| chr8:38,770,080–38,770,606 | 226.3 kb | Distal (>10kb) Multiome | 340 | |
| chr8:38,786,808–38,788,320 | 209.3 kb | Distal (>10kb) Multiome | 620 | |
| chr8:38,899,958–38,902,158 | 95.0 kb | Distal (>10kb) Multiome | 565 | |
| chr8:38,973,978–38,975,173 | 21.9 kb | Distal (>10kb) Multiome | 205 | |
| chr8:38,995,870–38,997,751 | 210 bp | At TSS Multiome | 913 | |
| chr8:39,004,744–39,005,067 | 8.2 kb | Proximal (<10kb) | 74 | |
| chr8:39,029,145–39,029,788 | 32.9 kb | Distal (>10kb) Multiome | 74 |
Genomic view of the TM2D2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.