The protein encoded by this gene is an orphan homeobox protein that encodes a DNA-binding nuclear transcription factor. A translocation [t(5;14)(q35;q32)] involving this gene is associated with T-cell acute lymphoblastic leukemia (T-ALL) in children and young adults. [provided by RefSeq, Nov 2015]
Transcription factors with Perturb-seq knockdown data for TLX3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TLX3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TLX3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:171,307,254–171,307,622 | 1.6 kb | Proximal (<10kb) | 96 | |
| chr5:171,308,499–171,310,470 | at TSS | At TSS | 460 | |
| chr5:171,310,975–171,311,886 | 1.7 kb | Proximal (<10kb) | 164 | |
| chr5:171,311,985–171,312,893 | 2.7 kb | Proximal (<10kb) | 142 | |
| chr5:171,314,774–171,315,878 | 5.5 kb | Proximal (<10kb) | 97 | |
| chr5:171,316,120–171,317,100 | 6.9 kb | Proximal (<10kb) | 101 | |
| chr5:171,318,003–171,318,466 | 8.8 kb | Proximal (<10kb) | 24 |
Genomic view of the TLX3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.