This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. [provided by RefSeq, Feb 2009]
Transcription factors with Perturb-seq knockdown data for TLN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TLN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TLN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:35,489,223–35,490,919 | 242.1 kb | Distal (>10kb) Multiome | 918 | |
| chr9:35,603,584–35,606,173 | 127.9 kb | Distal (>10kb) Multiome | 918 | |
| chr9:35,645,821–35,647,298 | 86.2 kb | Distal (>10kb) Multiome | 734 | |
| chr9:35,657,275–35,659,114 | 74.0 kb | Distal (>10kb) Multiome | 1156 | |
| chr9:35,664,903–35,665,580 | 66.9 kb | Distal (>10kb) Multiome | 814 | |
| chr9:35,675,371–35,676,451 | 56.2 kb | Distal (>10kb) Multiome | 223 | |
| chr9:35,689,224–35,691,525 | 40.9 kb | Distal (>10kb) Multiome | 541 | |
| chr9:35,729,814–35,729,984 | 2.1 kb | Proximal (<10kb) | 236 | |
| chr9:35,731,682–35,733,531 | 256 bp | At TSS Multiome | 920 | |
| chr9:35,736,174–35,736,592 | 4.1 kb | Proximal (<10kb) | 166 | |
| chr9:35,748,884–35,750,005 | 17.2 kb | Distal (>10kb) Multiome | 667 | |
| chr9:35,756,620–35,757,642 | 24.9 kb | Distal (>10kb) Multiome | 810 | |
| chr9:35,790,361–35,791,220 | 58.4 kb | Distal (>10kb) Multiome | 282 | |
| chr9:35,791,337–35,791,986 | 59.6 kb | Distal (>10kb) Multiome | 98 | |
| chr9:35,811,906–35,812,486 | 80.1 kb | Distal (>10kb) Multiome | 610 | |
| chr9:35,814,402–35,815,681 | 83.1 kb | Distal (>10kb) Multiome | 896 | |
| chr9:35,828,657–35,829,781 | 97.2 kb | Distal (>10kb) Multiome | 419 | |
| chr9:35,845,853–35,846,711 | 114.2 kb | Distal (>10kb) Multiome | 141 |
Genomic view of the TLN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.