This gene encodes a nuclear serine/threonine kinase that was first identified in Arabidopsis. The encoded protein is thought to function in the regulation of chromatin assembly in the S phase of the cell cycle by regulating the levels of a histone H3/H4 chaperone. This protein is associated with double-strand break repair of DNA damage caused by radiation. Pseudogenes of this gene are present on chromosomes 10 and 17. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Transcription factors with Perturb-seq knockdown data for TLK2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TLK2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TLK2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:62,423,543–62,424,436 | 55.1 kb | Distal (>10kb) Multiome | 604 | |
| chr17:62,477,989–62,479,448 | 360 bp | At TSS Multiome | 323 | |
| chr17:62,617,005–62,618,105 | 138.4 kb | Distal (>10kb) Multiome | 481 | |
| chr17:62,626,684–62,628,608 | 148.4 kb | Distal (>10kb) Multiome | 557 | |
| chr17:62,652,264–62,654,102 | 174.3 kb | Distal (>10kb) Multiome | 643 | |
| chr17:62,703,431–62,705,528 | 225.0 kb | Distal (>10kb) Multiome | 653 | |
| chr17:62,705,630–62,706,390 | 226.9 kb | Distal (>10kb) Multiome | 153 |
Genomic view of the TLK2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.