Predicted to be involved in lipid homeostasis. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TLCD4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TLCD4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TLCD4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:94,819,759–94,820,829 | 297.0 kb | Distal (>10kb) Multiome | 576 | |
| chr1:94,854,217–94,855,200 | 262.7 kb | Distal (>10kb) Multiome | 530 | |
| chr1:94,925,541–94,928,082 | 190.1 kb | Distal (>10kb) Multiome | 926 | |
| chr1:95,072,438–95,073,470 | 44.5 kb | Distal (>10kb) Multiome | 851 | |
| chr1:95,116,608–95,118,188 | 20 bp | At TSS Multiome | 748 | |
| chr1:95,233,248–95,234,813 | 116.7 kb | Distal (>10kb) Multiome | 938 |
Genomic view of the TLCD4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.