The protein encoded by this gene is a membrane-associated protein that promotes lung carcinogenesis. The encoded protein may be involved in amino acid transport and glutathione metabolism since it can interact with a solute carrier family member (SLC3A2) and an isoform of gamma-glutamyltranspeptidase-like 3. An alternatively spliced variant encoding a protein that lacks a 32 aa internal segment showed the opposite effect, inhibiting lung cancer cell growth. Knockdown of this gene also inhibited lung carcinogenesis and tumor cell growth. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Transcription factors with Perturb-seq knockdown data for TLCD3A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TLCD3A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TLCD3A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:714,554–715,298 | 17.7 kb | Distal (>10kb) Multiome | 798 | |
| chr17:726,334–726,821 | 5.7 kb | Proximal (<10kb) | 128 | |
| chr17:731,870–733,144 | 138 bp | At TSS Multiome | 602 | |
| chr17:751,539–752,928 | 19.8 kb | Distal (>10kb) Multiome | 891 | |
| chr17:781,922–782,799 | 49.8 kb | Distal (>10kb) Multiome | 914 | |
| chr17:875,256–875,758 | 142.9 kb | Distal (>10kb) Multiome | 42 | |
| chr17:927,652–928,423 | 195.4 kb | Distal (>10kb) Multiome | 315 | |
| chr17:933,255–933,971 | 201.1 kb | Distal (>10kb) Multiome | 400 | |
| chr17:951,413–952,178 | 219.2 kb | Distal (>10kb) Multiome | 385 | |
| chr17:964,907–965,931 | 233.0 kb | Distal (>10kb) Multiome | 256 | |
| chr17:978,189–980,530 | 247.3 kb | Distal (>10kb) Multiome HiCAR | 639 | |
| chr17:996,479–997,532 | 264.3 kb | Distal (>10kb) Multiome HiCAR | 994 | |
| chr17:1,031,608–1,032,193 | 299.4 kb | Distal (>10kb) Multiome | 54 |
Genomic view of the TLCD3A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.