Involved in several processes, including membrane assembly; phospholipid homeostasis; and regulation of membrane lipid distribution. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TLCD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TLCD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TLCD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:28,466,531–28,467,034 | 261.1 kb | Distal (>10kb) Multiome | 179 | |
| chr17:28,551,965–28,553,140 | 175.3 kb | Distal (>10kb) Multiome | 557 | |
| chr17:28,570,861–28,571,983 | 156.4 kb | Distal (>10kb) Multiome | 701 | |
| chr17:28,576,649–28,577,524 | 150.9 kb | Distal (>10kb) Multiome | 652 | |
| chr17:28,598,491–28,599,842 | 128.8 kb | Distal (>10kb) Multiome | 810 | |
| chr17:28,621,936–28,622,562 | 105.6 kb | Distal (>10kb) Multiome | 55 | |
| chr17:28,644,541–28,645,596 | 82.7 kb | Distal (>10kb) Multiome | 795 | |
| chr17:28,661,635–28,662,527 | 65.8 kb | Distal (>10kb) Multiome | 809 | |
| chr17:28,710,720–28,712,813 | 16.5 kb | Distal (>10kb) Multiome | 892 | |
| chr17:28,717,030–28,718,784 | 10.0 kb | Distal (>10kb) Multiome | 492 | |
| chr17:28,718,918–28,720,313 | 8.1 kb | Proximal (<10kb) Multiome | 927 | |
| chr17:28,724,652–28,729,474 | 891 bp | At TSS Multiome | 1286 | |
| chr17:28,743,083–28,744,926 | 16.1 kb | Distal (>10kb) Multiome | 991 | |
| chr17:28,745,076–28,746,436 | 17.7 kb | Distal (>10kb) Multiome | 568 | |
| chr17:28,749,859–28,750,549 | 22.3 kb | Distal (>10kb) Multiome | 550 | |
| chr17:28,811,615–28,812,945 | 84.6 kb | Distal (>10kb) Multiome | 699 | |
| chr17:28,842,307–28,843,098 | 114.9 kb | Distal (>10kb) Multiome | 717 | |
| chr17:28,854,460–28,855,289 | 127.0 kb | Distal (>10kb) Multiome | 780 | |
| chr17:28,896,962–28,898,028 | 169.7 kb | Distal (>10kb) Multiome | 846 | |
| chr17:28,902,302–28,903,488 | 175.1 kb | Distal (>10kb) Multiome HiCAR | 967 | |
| chr17:28,950,281–28,952,708 | 223.7 kb | Distal (>10kb) Multiome | 989 | |
| chr17:28,984,463–28,984,954 | 256.7 kb | Distal (>10kb) Multiome | 33 | |
| chr17:28,985,971–28,986,457 | 258.3 kb | Distal (>10kb) Multiome | 123 | |
| chr17:29,005,841–29,006,414 | 278.1 kb | Distal (>10kb) Multiome | 707 |
Genomic view of the TLCD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.