Predicted to be involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion and nucleoplasm. Implicated in nuclear type mitochondrial complex I deficiency 31. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TIMMDC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TIMMDC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TIMMDC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:119,206,295–119,207,798 | 291.6 kb | Distal (>10kb) Multiome | 256 | |
| chr3:119,210,998–119,211,738 | 287.1 kb | Distal (>10kb) Multiome | 234 | |
| chr3:119,240,068–119,241,279 | 257.7 kb | Distal (>10kb) Multiome | 820 | |
| chr3:119,241,393–119,241,941 | 256.8 kb | Distal (>10kb) Multiome | 393 | |
| chr3:119,293,740–119,295,412 | 204.4 kb | Distal (>10kb) Multiome | 540 | |
| chr3:119,322,394–119,324,118 | 175.6 kb | Distal (>10kb) Multiome | 824 | |
| chr3:119,349,421–119,349,961 | 148.9 kb | Distal (>10kb) Multiome | 181 | |
| chr3:119,350,134–119,350,644 | 148.2 kb | Distal (>10kb) Multiome | 175 | |
| chr3:119,360,851–119,361,645 | 137.2 kb | Distal (>10kb) Multiome | 107 | |
| chr3:119,417,868–119,418,544 | 80.2 kb | Distal (>10kb) Multiome | 156 | |
| chr3:119,463,124–119,464,243 | 34.9 kb | Distal (>10kb) Multiome | 902 | |
| chr3:119,468,550–119,469,486 | 29.6 kb | Distal (>10kb) Multiome | 832 | |
| chr3:119,497,916–119,499,024 | 23 bp | At TSS Multiome | 886 | |
| chr3:119,579,336–119,580,732 | 81.3 kb | Distal (>10kb) Multiome | 519 | |
| chr3:119,676,820–119,677,853 | 178.8 kb | Distal (>10kb) Multiome HiCAR | 778 | |
| chr3:119,702,500–119,703,521 | 204.4 kb | Distal (>10kb) Multiome | 399 |
Genomic view of the TIMMDC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.