The protein encoded by this gene is part of a complex located in the inner mitochondrial membrane that mediates the transport of transit peptide-containing proteins across the membrane. Multiple transcript variants, one protein-coding and others not protein-coding, have been found for this gene. [provided by RefSeq, Jul 2012]
Transcription factors with Perturb-seq knockdown data for TIMM23. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TIMM23 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TIMM23, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:45,672,004–45,673,546 | 299.7 kb | Distal (>10kb) Multiome | 871 | |
| chr10:45,726,765–45,727,627 | 245.3 kb | Distal (>10kb) Multiome | 520 | |
| chr10:45,962,798–45,963,006 | 9.5 kb | Proximal (<10kb) | 5 | |
| chr10:45,972,130–45,972,583 | at TSS | At TSS | 358 | |
| chr10:46,023,121–46,023,829 | 50.9 kb | Distal (>10kb) Multiome | 900 | |
| chr10:46,030,064–46,031,227 | 58.1 kb | Distal (>10kb) Multiome | 853 | |
| chr10:46,047,885–46,048,755 | 75.8 kb | Distal (>10kb) Multiome | 277 | |
| chr10:46,052,126–46,053,175 | 80.1 kb | Distal (>10kb) Multiome | 517 | |
| chr10:46,106,177–46,107,298 | 134.2 kb | Distal (>10kb) Multiome | 610 | |
| chr10:46,228,286–46,229,571 | 256.9 kb | Distal (>10kb) Multiome HiCAR | 447 |
Genomic view of the TIMM23 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.