This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TIAM2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TIAM2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TIAM2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:154,542,675–154,543,191 | 452.3 kb | Distal (>10kb) Multiome | 171 | |
| chr6:154,645,535–154,646,800 | 349.0 kb | Distal (>10kb) Multiome | 96 | |
| chr6:154,652,848–154,653,591 | 342.1 kb | Distal (>10kb) Multiome | 127 | |
| chr6:154,732,598–154,734,903 | 261.2 kb | Distal (>10kb) Multiome | 1110 | |
| chr6:154,994,749–154,996,245 | 77 bp | At TSS Multiome | 572 | |
| chr6:155,313,962–155,315,220 | 319.3 kb | Distal (>10kb) Multiome | 1066 |
Genomic view of the TIAM2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.