The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms has been found for this gene. [provided by RefSeq, May 2017]
Transcription factors with Perturb-seq knockdown data for TIA1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TIA1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TIA1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:70,084,998–70,085,484 | 163.4 kb | Distal (>10kb) Multiome | 345 | |
| chr2:70,086,194–70,088,572 | 161.6 kb | Distal (>10kb) Multiome | 1204 | |
| chr2:70,089,216–70,090,447 | 158.9 kb | Distal (>10kb) Multiome | 459 | |
| chr2:70,123,128–70,125,445 | 125.2 kb | Distal (>10kb) Multiome | 779 | |
| chr2:70,140,819–70,143,188 | 106.0 kb | Distal (>10kb) Multiome | 1260 | |
| chr2:70,190,215–70,191,415 | 57.7 kb | Distal (>10kb) Multiome | 1013 | |
| chr2:70,248,096–70,249,173 | 29 bp | At TSS Multiome | 999 | |
| chr2:70,257,355–70,258,877 | 9.4 kb | Proximal (<10kb) Multiome | 879 | |
| chr2:70,283,629–70,284,233 | 35.2 kb | Distal (>10kb) Multiome | 27 | |
| chr2:70,293,224–70,294,270 | 45.0 kb | Distal (>10kb) Multiome | 956 | |
| chr2:70,301,251–70,302,453 | 53.3 kb | Distal (>10kb) Multiome | 1040 | |
| chr2:70,303,787–70,304,419 | 55.5 kb | Distal (>10kb) Multiome | 306 |
Genomic view of the TIA1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.