THY1

Thy-1 cell surface antigen | CD90

This gene encodes a cell surface glycoprotein and member of the immunoglobulin superfamily of proteins. The encoded protein is involved in cell adhesion and cell communication in numerous cell types, but particularly in cells of the immune and nervous systems. The encoded protein is widely used as a marker for hematopoietic stem cells. This gene may function as a tumor suppressor in nasopharyngeal carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

Developmental clusters: GC4

Biological processes 67 terms

GPI anchor binding (GO:0034235)GTPase activator activity (GO:0005096)GTPase activator activity (GO:0005096)T cell receptor signaling pathway (GO:0050852)angiogenesis (GO:0001525)angiogenesis (GO:0001525)apical plasma membrane (GO:0016324)axolemma (GO:0030673)cell adhesion (GO:0007155)cell surface (GO:0009986)cell surface (GO:0009986)cell surface receptor signaling pathway (GO:0007166)cell-cell adhesion (GO:0098609)cell-cell signaling (GO:0007267)cell-cell signaling (GO:0007267)cytoskeleton organization (GO:0007010)dendrite (GO:0030425)dendrite (GO:0030425)dendrite membrane (GO:0032590)endoplasmic reticulum (GO:0005783)external side of plasma membrane (GO:0009897)external side of plasma membrane (GO:0009897)external side of plasma membrane (GO:0009897)extracellular exosome (GO:0070062)extracellular region (GO:0005576)focal adhesion (GO:0005925)focal adhesion assembly (GO:0048041)glutamatergic synapse (GO:0098978)growth cone (GO:0030426)heterotypic cell-cell adhesion (GO:0034113)integrin binding (GO:0005178)integrin binding (GO:0005178)integrin binding (GO:0005178)integrin-mediated signaling pathway (GO:0007229)integrin-mediated signaling pathway (GO:0007229)integrin-mediated signaling pathway (GO:0007229)membrane raft (GO:0045121)membrane raft (GO:0045121)membrane raft (GO:0045121)negative regulation of T cell receptor signaling pathway (GO:0050860)negative regulation of T cell receptor signaling pathway (GO:0050860)negative regulation of axonogenesis (GO:0050771)negative regulation of cell migration (GO:0030336)negative regulation of neuron projection regeneration (GO:0070571)negative regulation of neuron projection regeneration (GO:0070571)negative regulation of protein kinase activity (GO:0006469)neuronal cell body membrane (GO:0032809)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of GTPase activity (GO:0043547)positive regulation of T cell activation (GO:0050870)positive regulation of cell adhesion (GO:0045785)positive regulation of cellular extravasation (GO:0002693)positive regulation of focal adhesion assembly (GO:0051894)positive regulation of focal adhesion assembly (GO:0051894)positive regulation of focal adhesion assembly (GO:0051894)positive regulation of release of sequestered calcium ion into cytosol (GO:0051281)postsynapse (GO:0098794)presynapse (GO:0098793)protein binding (GO:0005515)receptor clustering (GO:0043113)regulation of cell migration (GO:0030334)regulation of cell-matrix adhesion (GO:0001952)regulation of immune system process (GO:0002682)retinal cone cell development (GO:0046549)retinal cone cell development (GO:0046549)

Expression (TPM)

TFs regulating THY1 0 TFs

Transcription factors with Perturb-seq knockdown data for THY1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = THY1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to THY1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of THY1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr11:119,144,795–119,145,355	278.2 kb	Distal (>10kb) Multiome	230
chr11:119,148,816–119,149,933	273.8 kb	Distal (>10kb) Multiome	262
chr11:119,168,601–119,169,645	254.2 kb	Distal (>10kb) Multiome	794
chr11:119,205,241–119,207,150	217.1 kb	Distal (>10kb) Multiome	695
chr11:119,315,017–119,315,819	107.9 kb	Distal (>10kb) Multiome	270
chr11:119,316,693–119,317,760	105.9 kb	Distal (>10kb) Multiome	463
chr11:119,320,617–119,321,906	101.4 kb	Distal (>10kb) Multiome	516
chr11:119,334,140–119,334,815	88.8 kb	Distal (>10kb) Multiome	577
chr11:119,337,716–119,338,797	85.0 kb	Distal (>10kb) Multiome	412
chr11:119,339,587–119,340,902	83.1 kb	Distal (>10kb) Multiome	477
chr11:119,356,332–119,357,013	66.5 kb	Distal (>10kb) Multiome	366
chr11:119,363,939–119,364,561	59.0 kb	Distal (>10kb) Multiome	255
chr11:119,380,894–119,382,060	41.5 kb	Distal (>10kb) Multiome	800
chr11:119,421,972–119,422,277	921 bp	At TSS	90
chr11:119,422,349–119,423,771	67 bp	At TSS Multiome	235
chr11:119,481,243–119,481,846	58.4 kb	Distal (>10kb) Multiome	592
chr11:119,584,125–119,585,601	161.2 kb	Distal (>10kb) Multiome	491

Genome Browser

Genomic view of the THY1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.