The TREX multiprotein complex binds specifically to spliced mRNAs to facilitate mRNA export. The protein encoded by this gene is a member of the THO complex, a subset of the TREX complex. The encoded protein interacts with the THOC1 protein.[provided by RefSeq, Jun 2010]
Transcription factors with Perturb-seq knockdown data for THOC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = THOC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of THOC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:123,648,282–123,649,200 | 84.3 kb | Distal (>10kb) Multiome | 228 | |
| chrX:123,732,738–123,733,286 | at TSS | At TSS | 641 | |
| chrX:123,764,958–123,765,499 | 32.1 kb | Distal (>10kb) Multiome | 449 | |
| chrX:123,777,153–123,778,268 | 44.7 kb | Distal (>10kb) Multiome | 304 | |
| chrX:123,819,503–123,820,137 | 86.7 kb | Distal (>10kb) Multiome | 137 | |
| chrX:123,859,576–123,860,648 | 127.0 kb | Distal (>10kb) Multiome | 739 | |
| chrX:123,864,842–123,865,356 | 132.0 kb | Distal (>10kb) Multiome | 63 | |
| chrX:123,959,874–123,960,635 | 227.3 kb | Distal (>10kb) Multiome | 606 | |
| chrX:123,960,800–123,962,121 | 228.6 kb | Distal (>10kb) Multiome | 588 | |
| chrX:123,962,799–123,963,352 | 230.1 kb | Distal (>10kb) Multiome | 545 |
Genomic view of the THOC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.