Enables sequence-specific DNA binding activity and transposase activity. Involved in DNA integration and DNA transposition. Predicted to be located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for THAP9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = THAP9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of THAP9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:82,667,793–82,668,466 | 232.5 kb | Distal (>10kb) Multiome | 123 | |
| chr4:82,716,050–82,716,644 | 184.3 kb | Distal (>10kb) Multiome | 173 | |
| chr4:82,739,190–82,739,774 | 161.2 kb | Distal (>10kb) Multiome | 317 | |
| chr4:82,797,244–82,798,074 | 103.3 kb | Distal (>10kb) Multiome | 243 | |
| chr4:82,798,169–82,799,103 | 101.9 kb | Distal (>10kb) Multiome | 368 | |
| chr4:82,890,719–82,891,825 | 9.4 kb | Proximal (<10kb) Multiome | 1005 | |
| chr4:82,899,856–82,901,464 | 1 bp | At TSS Multiome | 977 | |
| chr4:83,010,137–83,011,179 | 110.0 kb | Distal (>10kb) Multiome | 601 | |
| chr4:83,012,161–83,013,775 | 112.3 kb | Distal (>10kb) Multiome | 913 | |
| chr4:83,034,341–83,035,668 | 134.3 kb | Distal (>10kb) Multiome | 993 | |
| chr4:83,109,433–83,110,778 | 209.1 kb | Distal (>10kb) Multiome | 591 |
Genomic view of the THAP9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.