The protein encoded by this gene is a dimethyltransferase that methylates the conserved stem loop of mitochondrial 12S rRNA. The encoded protein also is part of the basal mitochondrial transcription complex and is necessary for mitochondrial gene expression. The methylation and transcriptional activities of this protein are independent of one another. Variations in this gene may influence the severity of aminoglycoside-induced deafness (AID).[provided by RefSeq, Aug 2010]
Transcription factors with Perturb-seq knockdown data for TFB1M. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TFB1M upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TFB1M, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:155,313,962–155,315,220 | 183 bp | At TSS Multiome | 1066 | |
| chr6:156,400,866–156,402,632 | 1086.9 kb | Distal (>10kb) Multiome HiCAR | 206 | |
| chr6:156,556,716–156,558,143 | 1243.2 kb | Distal (>10kb) Multiome HiCAR | 309 | |
| chr6:156,655,335–156,656,025 | 1341.3 kb | Distal (>10kb) Multiome HiCAR | 157 | |
| chr6:156,776,956–156,780,648 | 1463.0 kb | Distal (>10kb) Multiome HiCAR | 985 | |
| chr6:156,944,408–156,944,838 | 1630.2 kb | Distal (>10kb) Multiome HiCAR | 86 | |
| chr6:157,020,971–157,022,582 | 1707.1 kb | Distal (>10kb) Multiome HiCAR | 1105 | |
| chr6:157,274,253–157,275,484 | 1960.5 kb | Distal (>10kb) Multiome HiCAR | 761 | |
| chr6:157,304,187–157,305,043 | 1990.3 kb | Distal (>10kb) Multiome HiCAR | 74 |
Genomic view of the TFB1M locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.