This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Transcription factors with Perturb-seq knockdown data for TFAM. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TFAM upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TFAM, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:58,140,507–58,141,288 | 244.5 kb | Distal (>10kb) Multiome | 122 | |
| chr10:58,266,789–58,269,963 | 117.5 kb | Distal (>10kb) Multiome | 1224 | |
| chr10:58,334,610–58,335,934 | 50.4 kb | Distal (>10kb) Multiome | 801 | |
| chr10:58,384,591–58,386,114 | 77 bp | At TSS Multiome | 1000 | |
| chr10:58,393,188–58,393,877 | 7.8 kb | Proximal (<10kb) | 25 | |
| chr10:58,512,205–58,513,965 | 127.6 kb | Distal (>10kb) Multiome | 523 | |
| chr10:58,576,755–58,577,603 | 191.8 kb | Distal (>10kb) Multiome | 159 |
Genomic view of the TFAM locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.