Enables signaling receptor activity. Involved in protein-DNA covalent cross-linking repair. Acts upstream of or within reticulophagy. Located in several cellular components, including autophagosome membrane; endoplasmic reticulum membrane; and replication fork. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TEX264. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TEX264 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TEX264, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:50,226,120–50,228,328 | 1445.1 kb | Distal (>10kb) Multiome HiCAR | 915 | |
| chr3:50,611,315–50,612,530 | 1059.3 kb | Distal (>10kb) Multiome HiCAR | 904 | |
| chr3:50,615,997–50,617,867 | 1054.1 kb | Distal (>10kb) Multiome HiCAR | 754 | |
| chr3:51,384,278–51,385,586 | 286.2 kb | Distal (>10kb) Multiome | 787 | |
| chr3:51,390,699–51,392,749 | 280.1 kb | Distal (>10kb) Multiome HiCAR | 824 | |
| chr3:51,499,159–51,500,640 | 171.2 kb | Distal (>10kb) Multiome HiCAR | 838 | |
| chr3:51,538,310–51,539,294 | 132.6 kb | Distal (>10kb) Multiome | 974 | |
| chr3:51,669,307–51,669,595 | 1.7 kb | Proximal (<10kb) | 348 | |
| chr3:51,670,855–51,672,297 | 54 bp | At TSS Multiome | 799 | |
| chr3:51,681,945–51,682,394 | 11.0 kb | Distal (>10kb) Multiome | 291 | |
| chr3:51,706,614–51,707,579 | 35.7 kb | Distal (>10kb) Multiome | 506 | |
| chr3:51,798,234–51,798,899 | 127.4 kb | Distal (>10kb) Multiome | 120 | |
| chr3:51,800,441–51,801,024 | 129.3 kb | Distal (>10kb) Multiome | 20 | |
| chr3:51,801,591–51,802,872 | 131.1 kb | Distal (>10kb) Multiome | 223 | |
| chr3:51,868,646–51,869,606 | 197.8 kb | Distal (>10kb) Multiome | 50 | |
| chr3:51,941,340–51,942,909 | 270.8 kb | Distal (>10kb) Multiome | 890 | |
| chr3:51,955,723–51,956,827 | 285.3 kb | Distal (>10kb) Multiome | 289 | |
| chr3:51,967,071–51,968,598 | 296.3 kb | Distal (>10kb) Multiome | 581 |
Genomic view of the TEX264 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.