Predicted to enable COPII receptor activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Predicted to act upstream of or within positive regulation of apoptotic process. Predicted to be located in cytoplasm and membrane. Predicted to be active in COPII-coated ER to Golgi transport vesicle; Golgi membrane; and endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TEX261. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TEX261 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TEX261, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:70,767,008–70,768,580 | 226.6 kb | Distal (>10kb) Multiome | 463 | |
| chr2:70,887,498–70,887,945 | 107.1 kb | Distal (>10kb) Multiome | 377 | |
| chr2:70,888,885–70,889,375 | 105.6 kb | Distal (>10kb) Multiome | 192 | |
| chr2:70,899,864–70,901,996 | 94.4 kb | Distal (>10kb) Multiome | 834 | |
| chr2:70,976,676–70,977,663 | 17.6 kb | Distal (>10kb) Multiome | 372 | |
| chr2:70,978,404–70,979,416 | 15.9 kb | Distal (>10kb) Multiome | 229 | |
| chr2:70,984,781–70,985,145 | 9.7 kb | Proximal (<10kb) | 252 | |
| chr2:70,994,406–70,995,235 | 96 bp | At TSS Multiome | 805 | |
| chr2:70,995,330–70,995,669 | 457 bp | At TSS | 361 | |
| chr2:71,001,145–71,001,559 | 6.3 kb | Proximal (<10kb) | 583 | |
| chr2:71,002,259–71,002,506 | 7.4 kb | Proximal (<10kb) | 98 | |
| chr2:71,067,597–71,069,479 | 73.7 kb | Distal (>10kb) Multiome | 1161 | |
| chr2:71,103,036–71,103,639 | 108.5 kb | Distal (>10kb) Multiome | 56 | |
| chr2:71,129,728–71,130,863 | 135.5 kb | Distal (>10kb) Multiome | 1092 | |
| chr2:71,226,288–71,227,849 | 232.4 kb | Distal (>10kb) Multiome | 657 | |
| chr2:71,276,206–71,277,158 | 281.7 kb | Distal (>10kb) Multiome | 790 |
Genomic view of the TEX261 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.